Translational control of cell growth and malignancy by the CPEBs.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 23446545.
- Also identified by DOI 10.1038/nrc3485.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The cytoplasmic polyadenylation element binding proteins (CPEBs) associate with specific sequences in mRNA 3' untranslated regions to promote translation. They do so by inducing cytoplasmic polyadenylation, which requires specialized poly(A) polymerases. Aberrant expression of these proteins correlates with certain types of cancer, indicating that cytoplasmic RNA 3' end processing is important in the control of growth. Several CPEB-regulated mRNAs govern cell cycle progression, regulate senescence, establish cell polarity, and promote tumorigenesis and metastasis. In this Opinion article, we discuss the emerging evidence that indicates a key role for the CPEBs in cancer biology.
Medical subject headings
- Neoplasms
- Protein Biosynthesis
- RNA, Messenger
- mRNA Cleavage and Polyadenylation Factors