Enzyme-free unlabeled DNA logic circuits based on toehold-mediated strand displacement and split G-quadruplex enhanced fluorescence.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23447454.
- Also identified by DOI 10.1002/adma.201205360.
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Abstract
Adopting fluorescence of PPIX enhanced by a split G-quadruplex and toehold mediated strand displacement reaction, a series of unlabeled fluorescent logic gates is set up and some of them are cascaded into circuits. Controlled release of PPIX, which is also a photosensitizer in photodynamic diagnosis and therapy, is realized by this circuit, making it a wise choice for DNA computing.
Medical subject headings
- Computers, Molecular
- G-Quadruplexes
- Protoporphyrins
- Signal Processing, Computer-Assisted
- Spectrometry, Fluorescence