Silica-based branched hollow microfibers as a biomimetic extracellular matrix for promoting tumor cell growth in vitro and in vivo.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23450784.
- Also identified by DOI 10.1002/adma.201204472 and PMC identifier 3731149.
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Abstract
A novel scaffold composed of loosely branched hollow silica microfibers that has been proven to be highly biocompatible is proposed for the 3D culture of cancer cells. The MCF-7 cancer cells can grow and proliferate freely inside the scaffold in the form of multicellular spheroids. MCF-7 cancer cells cultured on the current 3D silica scaffold retained significantly more oncological characters than those cultured on the conventional 2D substrate and can serve as in vitro tumor model for studying cancer treatment.
Medical subject headings
- Biomimetic Materials
- Extracellular Matrix
- Neoplasms, Experimental
- Silicon Dioxide
- Tissue Engineering
- Tissue Scaffolds