By hook or by crook: multifaceted DNA-binding properties of MeCP2.
review · Level V
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- Record sourced from PubMed, PMID 23452844.
- Also identified by DOI 10.1016/j.cell.2013.02.017 and PMC identifier 4119793.
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Abstract
Two new studies reveal novel DNA-binding properties of MeCP2, mutations of which cause Rett syndrome. Baker et al. report critical roles for the AT-hook domain of MeCP2 in chromatin organization and clinical features of Rett syndrome. Mellén et al. find the methyl-CpG-binding domain of MeCP2 interacts with hydroxymethyl-CpG.