Rapid-antigen detection tests for group a streptococcal pharyngitis: revisiting false-positive results using polymerase chain reaction testing.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 23465407.
- Also identified by DOI 10.1016/j.jpeds.2013.01.050.
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Abstract
We investigated mechanisms of the false-positive test results on rapid-antigen detection test (RADT) for group A Streptococcal (GAS) pharyngitis. Most RADT false-positives (76%) were associated with polymerase chain reaction-positive GAS results, suggesting that RADT specificity could be considered close to 100%. Finding that 61% of GAS culture-negative but RADT-positive cases were positive on both GAS polymerase chain reaction and Staphylococcus aureus testing, we posit bacterial inhibition as causative.
Medical subject headings
- Antigens, Bacterial
- Pharyngitis
- Pharynx
- Staphylococcus aureus
- Streptococcal Infections
- Streptococcus pyogenes