An inflammatory situation: SOX2 and STAT3 cooperate in squamous cell carcinoma initiation.
editorial · Level V
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- Record sourced from PubMed, PMID 23472866.
- Also identified by DOI 10.1016/j.stem.2013.02.004.
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Abstract
Although SOX2 has been identified as a squamous cell carcinoma oncogene, mechanisms of SOX2-induce oncogenesis have remained elusive. In this issue of Cell Stem Cell, Li et al. (2013) show that SOX2 synergizes with inflammation-induced STAT3 activation to transform basal progenitors and initiate squamous cell carcinoma.