Nocturnal hypoxaemia in patients with Eisenmenger syndrome: a cohort study.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 23482988.
- Also identified by DOI 10.1136/bmjopen-2012-002039 and PMC identifier 3612812.
- Licence recorded as CC BY-NC.
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Abstract
The objective of the study was to find the prevalence of sleep-related disturbances in patients of Eisenmenger syndrome. Prospective observational study. Tertiary care referral centre in North India. The study included 25 patients with Eisenmenger syndrome (mean age 25.2±9.6 years, 18 men) and 12 patients with cyanotic congenital heart disease with pulmonary stenosis physiology (mean age 20.5±8.5 years, 8 men) as controls. All the patients underwent an overnight comprehensive polysomnogram study and pulmonary function testing. Oxygen desaturation index, which is the number of oxygen drops per hour. The patients and controls had significant nocturnal hypoxaemia in the absence of apnoea and hypopnoea. The mean oxygen drop index in Eisenmenger syndrome group was 9.0±6.2 and in the control group was 8.0±5.9 (p=0.63). The apnoea-hypopnoea index was 3.37±5.0 in the Eisenmenger syndrome group and was 2.1±3.6 in the control group. Patients with >10 oxygen drops per hour had significantly higher haemoglobin (17.2±1.3% vs 14.4±1.5%, p<0.001) than those with oxygen drops less than 10. Eisenmenger syndrome patients have significant nocturnal hypoxaemia unrelated to hypopnoea and apnoea. Nocturnal desaturation occurred more frequently in patients with greater haemoglobin values.