Acellular biomaterials: an evolving alternative to cell-based therapies.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23486777.
- Also identified by DOI 10.1126/scitranslmed.3003997 and PMC identifier 4041107.
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Abstract
Acellular biomaterials can stimulate the local environment to repair tissues without the regulatory and scientific challenges of cell-based therapies. A greater understanding of the mechanisms of such endogenous tissue repair is furthering the design and application of these biomaterials. We discuss recent progress in acellular materials for tissue repair, using cartilage and cardiac tissues as examples of applications with substantial intrinsic hurdles, but where human translation is now occurring.
Medical subject headings
- Biocompatible Materials