An epigenetic roadmap for cardiomyocyte differentiation.
basic_science · Level V
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- Record sourced from PubMed, PMID 23493303.
- Also identified by DOI 10.1161/CIRCRESAHA.113.301134 and PMC identifier 4217199.
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Abstract
Wamstad et al have provided a robust global analysis of histone markers and gene expression at 4 stages of murine embryonic stem (ES) cell differentiation into cardiac myocytes. This detailed data set will provide a rich opportunity for generating and testing hypotheses related to combinatorial transcriptional regulation of gene expression and epigenetic regulation of cell fate decisions in cardiac lineages.