Oxime cross-linked injectable hydrogels for catheter delivery.

Grover, Gregory N; Braden, Rebecca L; Christman, Karen L · Adv Mater · 2013

basic_science · Level V

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Abstract

Catheter delivery of therapeutic materials is important for developing minimally invasive treatment approaches. However, the majority of injectable materials gel rapidly upon mixing and/or heating to body temperature. The application of an oxime cross-linked hydrogel system is demonstrated. The system has a broad range of tunable gelation rates, is capable of injection through a catheter, and exhibits rapid gelation upon injection into tissue.

Medical subject headings