Transcriptional regulation and its misregulation in disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23498934.
- Also identified by DOI 10.1016/j.cell.2013.02.014 and PMC identifier 3640494.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The gene expression programs that establish and maintain specific cell states in humans are controlled by thousands of transcription factors, cofactors, and chromatin regulators. Misregulation of these gene expression programs can cause a broad range of diseases. Here, we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease.
Medical subject headings
- Disease
- Gene Expression Regulation
- Transcription, Genetic