Precocious puberty following head injury. Case report.

Maxwell, M; Karacostas, D; Ellenbogen, R G; Brzezinski, A; Zervas, N T; Black, P M · J Neurosurg · 1990

case_report · Level V

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Abstract

A 6-year-old girl developed secondary sexual characteristics 5 months after severe closed head injury. Endocrinological tests confirmed a pubertal sexual condition; there was also diminution of serum melatonin and disruption of the diurnal pattern. Magnetic resonance imaging demonstrated focal hypothalamic injury; this is believed to be the first time such a posttraumatic lesion has been demonstrated by imaging techniques. The pathophysiology of this condition is discussed.

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