Unilateral humoral rejection after reoperative single-lung transplant.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 23522237.
- Also identified by DOI 10.1016/j.athoracsur.2012.09.089 and PMC identifier 4128897.
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Abstract
The role of antibody-mediated rejection in acute and chronic rejection after lung transplantation is poorly understood. We report the case of a prior single-lung transplant recipient undergoing an acute antibody-mediated rejection isolated to her new, contralateral single-lung transplant. A 44-year-old woman 6 years after undergoing a single-lung transplant for idiopathic pulmonary fibrosis underwent a second single-lung transplant for bronchiolitis obliterans syndrome. Despite a negative crossmatch, she subsequently exhibited severe antibody-mediated rejection to her new allograft within 6 days of transplantation. The process of allograft sensitization is dynamic, and further study is warranted to better understand this process.
Medical subject headings
- Bronchiolitis Obliterans
- Graft Rejection
- HLA Antigens
- Immunity, Humoral
- Lung Transplantation