WNT signaling in stem cell differentiation and tumor formation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23524963.
- Also identified by DOI 10.1172/JCI69324 and PMC identifier 3613938.
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Abstract
Embryonic stem cells (ESCs) hold great therapeutic promise for the regeneration of functional cell types and clinical applications. However, tumorigenic potential of stem cells in a transplanted host remains a major obstacle. In this issue of the JCI, Cui and colleagues identified TCF7-mediated canonical WNT signaling as a critical determinant of both the tumorigenicity and therapeutic function of ESC-derived retinal progenitor cells (ESC-RPCs). Their findings suggested that addressing key extracellular signaling and related intrinsic factors will be essential for the successful use of ESC-derived progenitor transplantation.
Medical subject headings
- Cell Transformation, Neoplastic
- Embryonic Stem Cells
- Eye Neoplasms
- Wnt Signaling Pathway