Combination delivery of antigens and CpG by lanthanides-based core-shell nanoparticles for enhanced immune response and dual-mode imaging.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23526798.
- Also identified by DOI 10.1002/adhm.201200364.
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Abstract
Europium-doped GdPO4 hollow spheres/polymer core-shell nanoparticles are functionalized with ovalbumin (OVA) as a model antigen and an oligonucleotide (CpG) that stimulates the immune response. These functionalized core-shell nanoparticles are used as vaccines, where they enable efficient delivery of an antigen to target sites, tracking of the vaccines using non-invasive clinical imaging technology.
Medical subject headings
- Antigens
- Lanthanoid Series Elements
- Metal Nanoparticles
- Oligodeoxyribonucleotides