High-purity prostate circulating tumor cell isolation by a polymer nanofiber-embedded microchip for whole exome sequencing.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23529932.
- Also identified by DOI 10.1002/adma.201205237 and PMC identifier 3875622.
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Abstract
Handpick single cancer cells: a modified NanoVelcro Chip is coupled with ArcturusXT laser capture microdissection (LCM) technology to enable the detection and isolation of single circulating tumor cells (CTCs) from patients with prostate cancer (PC). This new approach paves the way for conducting next-generation sequencing (NGS) on single CTCs.
Medical subject headings
- Cell Separation
- Exome
- Microchip Analytical Procedures
- Nanofibers
- Neoplastic Cells, Circulating
- Prostatic Neoplasms
- Sequence Analysis, DNA