To activate or not to activate: the existential dilemma of an enhancer.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23538274.
- Also identified by DOI 10.1161/CIRCRESAHA.113.301133 and PMC identifier 5520998.
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Abstract
In a recent study, Watanabe et al identify a novel enhancer in the fgf10 locus that is necessary and sufficient for expression in anterior second heart field. Their results suggest a competitive mechanism in which Isl1 and Nkx2-5 bind the enhancer to activate or repress this enhancer, respectively.
Medical subject headings
- Fibroblast Growth Factor 10
- Gene Expression Regulation, Developmental
- Genes, Switch
- Heart
- Homeodomain Proteins
- LIM-Homeodomain Proteins
- T-Box Domain Proteins
- Transcription Factors