Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease.
Level V
Where this comes from
- Record sourced from PubMed, PMID 23538692.
- Also identified by DOI 10.1038/ki.2012.434 and PMC identifier 3616333.
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Abstract
Watanabe et al. report that Nox4 NADPH oxidase catalytic moiety and the subunit p22(phox) mediate the increase in oxidative stress and human tubular epithelial cell injury induced by p-cresyl sulfate, a protein-bound uremic toxin. These findings could be instrumental for the design of novel therapeutic intervention utilizing small-molecule inhibitors specifically targeting Nox oxidases to prevent or slow down the progression of chronic kidney disease and the associated disorders due to uremic toxicity.
Medical subject headings
- Cresols
- Epithelial Cells
- Kidney Tubules, Proximal
- NADPH Oxidases
- Oxidative Stress
- Renal Insufficiency, Chronic
- Sulfuric Acid Esters