A revolution coming to a classic model organism.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 23538865.
- Also identified by DOI 10.1038/nmeth.2415 and PMC identifier 4828911.
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Abstract
Classic gene targeting and gene replacement can now be achieved in zebrafish after cleaving the genome with engineered nucleases in the presence of donor DNA. This simple-to-implement method enables new classes of biological study in this important model organism.
Medical subject headings
- Deoxyribonucleases
- Recombination, Genetic
- Zebrafish