Photoredox activation for the direct β-arylation of ketones and aldehydes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23539600.
- Also identified by DOI 10.1126/science.1232993 and PMC identifier 3723331.
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Abstract
The direct β-activation of saturated aldehydes and ketones has long been an elusive transformation. We found that photoredox catalysis in combination with organocatalysis can lead to the transient generation of 5π-electron β-enaminyl radicals from ketones and aldehydes that rapidly couple with cyano-substituted aryl rings at the carbonyl β-position. This mode of activation is suitable for a broad range of carbonyl β-functionalization reactions and is amenable to enantioselective catalysis.
Medical subject headings
- Aldehydes
- Ketones
- Photochemical Processes