Synovial sarcoma mechanisms: a series of unfortunate events.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23540685.
- Also identified by DOI 10.1016/j.cell.2013.03.015.
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Abstract
Human synovial sarcoma is caused by a chromosome translocation, which fuses DNA encoding SSX to that encoding the SS18 protein. Kadoch and Crabtree now show that the resulting cellular transformation stems from disruption of the normal architecture and function of the human SWI/SNF (BAF) complex.