Ring around the Ro-sie: RNA-mediated alterations of PNPase activity.
basic_science · Level V
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- Record sourced from PubMed, PMID 23540686.
- Also identified by DOI 10.1016/j.cell.2013.03.005 and PMC identifier 3733347.
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Abstract
Chen et al. demonstrate a new way by which noncoding RNAs tailor the function of multicomponent complexes. They show that a noncoding RNA interacts with an exoribonuclease, altering its substrate specificity and enzymatic activity by serving as a ribonucleoprotein scaffold and, perhaps, a gate for entry of the RNA substrate.