Cullins getting undressed by the protein exchange factor Cand1.
basic_science · Level V
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- Record sourced from PubMed, PMID 23540687.
- Also identified by DOI 10.1016/j.cell.2013.03.014.
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Abstract
Cullin-RING ubiquitin ligase complexes (CRLs) rely on a vast array of adaptor proteins to recognize their substrates. Pierce et al. and related papers from Zemla et al. and Wu et al. in Nature Communications show that Cand1 promotes exchange of adaptor proteins to regulate the CRL repertoire.