Hydroxychloroquine preferentially induces apoptosis of CD45RO+ effector T cells by inhibiting autophagy: a possible mechanism for therapeutic modulation of T cells.
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- Record sourced from PubMed, PMID 23541328.
- Also identified by DOI 10.1016/j.jaci.2013.02.026 and PMC identifier 3955204.
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Abstract
Although hydroxychloroquine is used for treatment of numerous autoimmune disorders the mechanism is unclear. We here demonstrate that hydroxychloroquine preferentially induces apoptosis of CD45RO+ memory and effector T cells by inhibiting the survival pathway of autophagy.
Medical subject headings
- Apoptosis
- Autophagy
- CD4-Positive T-Lymphocytes
- Hydroxychloroquine
- Immunosuppressive Agents