Plasmonic imaging of brownian motion of single DNA molecules spontaneously binding to Ag nanoparticles.
basic_science · Level V
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- Record sourced from PubMed, PMID 23547650.
- Also identified by DOI 10.1021/nl304247n.
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Abstract
We find the spontaneous binding of single DNA molecules to uncoated silver nanoparticles (AgNPs) in aqueous solution with Mn(2+) (3 mM). From dark-field optical microscopic imaging of AgNPs bound to DNA molecules, we demonstrate analysis of the Brownian motion of single DNA molecules via plasmon resonance elastic light scattering. Our results provide that the plasmonic imaging technique is free from photobleaching and blinking and thus is useful in long-time observations of single-molecule DNA dynamics.
Medical subject headings
- DNA
- Metal Nanoparticles
- Silver
- Surface Plasmon Resonance