FOXO4 is necessary for neural differentiation of human embryonic stem cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23551888.
- Also identified by DOI 10.1111/acel.12067 and PMC identifier 4864013.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Proteostasis is critical for maintaining cell function and proteome stability may play an important role in human embryonic stem cell (hESC) immortality. Notably, hESC populations exhibit a high assembly of active proteasomes, a key node of the proteostasis network. FOXO4, an insulin/IGF-1 responsive transcription factor, regulates proteasome activity in hESCs. We find that loss of FOXO4 reduces the potential of hESCs to differentiate into neural lineages. Therefore, FOXO4 crosses evolutionary boundaries and links hESC function to invertebrate longevity modulation.
Medical subject headings
- Embryonic Stem Cells
- Neurogenesis
- Neurons
- Transcription Factors