Short telomeres flirt with stem cell commitment.
editorial · Level V
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- Record sourced from PubMed, PMID 23561436.
- Also identified by DOI 10.1016/j.stem.2013.03.011.
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Abstract
High expression of telomerase in embryonic stem cells (ESCs) is important for their maintenance, but whether telomere length affects lineage commitment is unknown. In this issue of Cell stem cell, Pucci et al. (2013) reveal that ESCs with short telomeres exhibit unstable differentiation by inducing altered DNA methylation.