If a stem cell dies in the crypt, and no one is around to see it….
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23561439.
- Also identified by DOI 10.1016/j.stem.2013.03.009.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Two recent studies continue the debate regarding lineage and hierarchy in the intestinal epithelium. One reports that quiescent crypt cells are Paneth cell precursors (Buczacki et al., 2013). The second shows that tamoxifen induces apoptosis in crypt cells and that suppressing apoptosis alters lineage tracing patterns (Zhu et al., 2013).