Insulin and ventral tegmental dopamine: what's impaired and what's intact?
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- Record sourced from PubMed, PMID 23562071.
- Also identified by DOI 10.1016/j.cmet.2013.03.011.
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Abstract
Manipulations affecting mesolimbic dopamine transmission exert specific effects on normal and pathological aspects of motivation, altering some functions while sparing others. Labouèbe et al. (2013) show that insulin induced long-term depression in ventral tegmental neurons, which was associated with reduced responsiveness to food-related stimuli but spared aspects of food-seeking behavior.