Altered cholesterol homeostasis in aged macrophages linked to neovascular macular degeneration.
basic_science · Level V
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- Record sourced from PubMed, PMID 23562072.
- Also identified by DOI 10.1016/j.cmet.2013.03.010 and PMC identifier 3669899.
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Abstract
Abnormal lipid metabolism has been linked to age-related macular degeneration (AMD); choroidal neovascularization in late AMD commonly causes blindness. Sene et al. (2013) now demonstrate that in aged macrophages decreased ABCA1 expression, regulated by liver X receptor and miR-33, impairs export of intracellular cholesterol, which promotes neovascular AMD.