Polybetaine modification of PDMS microfluidic devices to resist thrombus formation in whole blood.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23563730.
- Also identified by DOI 10.1039/c3lc50302j.
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Abstract
Assembled polydimethylsiloxane microfluidic devices were modified with a sulfobetaine polymer through continuous "tip-to-tip" modification, significantly reducing blood clotting and extending device patency under blood flow. This technology can be designed to enable the development of devices that can continuously work in whole blood, especially in an extracorporeal or in vivo environment.
Medical subject headings
- Dimethylpolysiloxanes
- Microfluidic Analytical Techniques
- Polymers
- Thrombosis