Human erythrocytes covered with magnetic core-shell nanoparticles for multimodal imaging.

Laurencin, Mathieu; Cam, Nithavong; Georgelin, Thomas; Clément, Olivier; Autret, Gwennhael; Siaugue, Jean-Michel; Ménager, Christine · Adv Healthc Mater · 2013

basic_science · Level V

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Abstract

Surface functionalization of human red blood cells (hRBCs) with fluorescent and magnetic silica core-shell nanoparticles is used to design a carrier suitable for multimodal imaging with a long circulating time. The coated magnetic hRBCs show no hemolytic activity, while the advantage of the affinity of proteins for silica allows a further coating.

Medical subject headings