Shedding new light on circadian clocks.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 23580350.
- Also identified by DOI 10.7554/eLife.00659 and PMC identifier 3622228.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Using a clever combination of genetic and biochemical tools researchers have shown that a transcription factor called USF1 has a central role in determining how mutations of the Clock gene manifest themselves in the behaviour of different mouse strains.
Medical subject headings
- ARNTL Transcription Factors
- CLOCK Proteins
- Circadian Clocks
- Circadian Rhythm
- DNA
- Mutation
- Upstream Stimulatory Factors