Opening up new fronts in the fight against cholesterol.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23580362.
- Also identified by DOI 10.7554/eLife.00663 and PMC identifier 3622229.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
An unexpected connection between a secretory protein called PCSK9 and Sec24A, a well known protein-transport protein, could lead to the development of novel treatments for patients with high levels of low-density lipoproteins in their blood.
Medical subject headings
- COP-Coated Vesicles
- Cholesterol
- Dyslipidemias
- Endoplasmic Reticulum
- Liver
- Proprotein Convertases
- Serine Endopeptidases
- Vesicular Transport Proteins