A therapy for liver failure found in the JNK yard.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23582318.
- Also identified by DOI 10.1016/j.cell.2013.03.033 and PMC identifier 4169283.
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Abstract
In the liver, the hepatocyte mass is kept stable through a tight balance between hepatocyte death and proliferation that is frequently lost upon acute or chronic liver injury. Wuestefeld et al. (2013) now identify a potentially druggable target that enhances hepatocyte proliferation and promotes liver regeneration, thereby preventing liver failure.