Higher-order assemblies in a new paradigm of signal transduction.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23582320.
- Also identified by DOI 10.1016/j.cell.2013.03.013 and PMC identifier 3687143.
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Abstract
Recent studies have revealed that multiple intracellular signaling proteins may assemble into structured, yet sometimes infinite, higher-order signaling machines for transmission of receptor activation information to cellular responses. These studies advance our understanding of cell signaling and implicate new molecular mechanisms in proximity-driven enzyme activation, threshold behavior, signal amplification, reduction of biological noise, and temporal and spatial control of signal transduction.
Medical subject headings
- Receptors, Cell Surface
- Signal Transduction