Triggered drug release from superhydrophobic meshes using high-intensity focused ultrasound.

Yohe, Stefan T; Kopechek, Jonathan A; Porter, Tyrone M; Colson, Yolonda L; Grinstaff, Mark W · Adv Healthc Mater · 2013

basic_science · Level V

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Abstract

Application of high-intensity focused ultrasound to drug-loaded superhydrophobic meshes affords triggered drug release by displacing an entrapped air layer. The air layer within the superhydrophobic meshes is characterized using direct visualization and B-mode imaging. Drug-loaded superhydrophobic meshes are cytotoxic in an in vitro assay after ultrasound treatment.

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