Genetic evaluation of the performance of malaria parasite clearance rate metrics.
Where this comes from
- Record sourced from PubMed, PMID 23592863.
- Also identified by DOI 10.1093/infdis/jit165 and PMC identifier 3685230.
- Licence recorded as CC BY-NC-ND.
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Abstract
Accurate measurement of malaria parasite clearance rates (CRs) following artemisinin (ART) treatment is critical for resistance surveillance and research, and various CR metrics are currently used. We measured 13 CR metrics in 1472 ART-treated hyperparasitemia infections for which 6-hour parasite counts and parasite genotypes (93 single nucleotide polymorphisms [SNPs]) were available. We used heritability to evaluate the performance of each metric. Heritability ranged from 0.06 ± 0.06 (SD) for 50% parasite clearance times to 0.67 ± 0.04 (SD) for clearance half-lives estimated from 6-hour parasite counts. These results identify the measures that should be avoided and show that reliable clearance measures can be obtained with abbreviated monitoring protocols.
Medical subject headings
- Malaria, Falciparum
- Parasitemia
- Plasmodium falciparum