SLC1A2 variant associated with essential tremor but not Parkinson disease in Chinese subjects.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 23596072.
- Also identified by DOI 10.1212/WNL.0b013e31828f1903.
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Abstract
Essential tremor (ET) is characterized by postural and action tremor.(1-3) A genome-wide association study (GWAS) identified a LINGO1 gene variant to be associated with ET.(4) Subsequent GWAS further identified an intronic variant (rs3794087) of the main glial glutamate transporter (SLC1A2) gene to be associated with ET with an odds ratio (OR) of approximately 1.4.(5) We conducted a case-control study to examine the SLC1A2 gene variant in an Asian cohort of ET. In addition, we also investigated the variant in patients with Parkinson disease (PD) because the GWAS LINGO1 variant has been implicated in both ET and PD and etiologic links between the conditions have been suggested.(6.)
Medical subject headings
- Essential Tremor
- Glutamate Plasma Membrane Transport Proteins
- Parkinson Disease