Using ultradeep pyrosequencing to study HIV-1 coreceptor usage in primary and dual infection.
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- Record sourced from PubMed, PMID 23599311.
- Also identified by DOI 10.1093/infdis/jit168 and PMC identifier 3685231.
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Abstract
HIV-1 dual infection (DI) and CXCR4 (X4) coreceptor usage are associated with accelerated disease progression but frequency and dynamics of coreceptor usage during DI is unknown. Ultradeep sequencing was used to interrogate for DI and infer coreceptor usage in longitudinal blood samples of 102 subjects. At baseline, X4 usage was high (23 subjects harbored X4 variants) and was not associated with infection duration or DI. Coreceptor usage changed over time in 12 of 47 participants, and X4 usage emerged in 4 of 41 monoinfections vs 2 of 5 superinfections (P = .12), suggesting a weak statistical trend toward occurrence of superinfection and acquiring X4 usage.
Medical subject headings
- HIV Infections
- HIV-1