Comment on "Drosophila dosage compensation involves enhanced Pol II recruitment to male X-linked promoters".
editorial · Level V
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- Record sourced from PubMed, PMID 23599463.
- Also identified by DOI 10.1126/science.1231815 and PMC identifier 3665607.
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Abstract
Conrad et al. (Reports, 10 August 2012, p. 742) reported a doubling of RNA polymerase II (Pol II) occupancy at X-linked promoters to support 5' recruitment as the key mechanism for dosage compensation in Drosophila. However, they employed an erroneous data-processing step, overestimating Pol II differences. Reanalysis of the data fails to support the authors' model for dosage compensation.
Medical subject headings
- DNA Polymerase II
- Dosage Compensation, Genetic
- Drosophila
- Drosophila Proteins
- Genes, X-Linked
- Promoter Regions, Genetic
- X Chromosome