Comment on "Drosophila dosage compensation involves enhanced Pol II recruitment to male X-linked promoters".
editorial · Level V
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- Record sourced from PubMed, PMID 23599464.
- Also identified by DOI 10.1126/science.1231895.
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Abstract
Conrad et al. (Reports, 10 August 2012, p. 742) reported that Drosophila dosage compensation might largely be due to increased recruitment of RNA polymerase II to promoters. A reassessment of the numerical operations revealed that the authors' calculations are severely confounded by an inappropriate numerical procedure. A rectified analysis strongly suggests that the authors' conclusions are not supported by their data.
Medical subject headings
- DNA Polymerase II
- Dosage Compensation, Genetic
- Drosophila
- Drosophila Proteins
- Genes, X-Linked
- Promoter Regions, Genetic
- X Chromosome