Antibody-functionalized magnetic polymersomes: in vivo targeting and imaging of bone metastases using high resolution MRI.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23606565.
- Also identified by DOI 10.1002/adhm.201300061.
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Abstract
Multifunctional polymersomes loaded with maghemite nanoparticles and grafted with an antibody, directed against human endothelial receptor 2, are developed as novel MRI contrast agents for bone metastasis imaging. Upon administration in mice bearing bone tumor grown from human breast cancer cells, MR images show targeting and enhanced retention of antibody-labeled polymersomes at the tumor site.
Medical subject headings
- Antibodies
- Bone Neoplasms
- Magnetic Phenomena
- Magnetic Resonance Imaging
- Polymers