Mouse models of Kras-mutant colorectal cancer: valuable GEMMs for drug testing?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23613316.
- Also identified by DOI 10.1158/1078-0432.CCR-13-0339.
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Abstract
The development of effective therapies for colorectal cancer depends on the ability of preclinical models to faithfully recapitulate the molecular and biologic behavior of human tumors. This study reports on the characterization of colorectal genetically engineered mouse models and their derivative cell lines carrying wild-type or oncogenic Kras with concomitant Apc and p53 loss.
Medical subject headings
- Colonic Neoplasms
- Mutation
- ras Proteins