Microenvironmental induced essentiality of autophagy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23613319.
- Also identified by DOI 10.1158/1078-0432.CCR-13-0634 and PMC identifier 4248230.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Angiogenesis inhibitors cause increased hypoxia in tumors and this results in the induction of cytoprotective autophagy. Targeting this adaptation using autophagy inhibitors can overcome resistance to antiangiogenic therapy and enhance the antitumor effects.
Medical subject headings
- Angiogenesis Inhibitors
- Antineoplastic Agents
- Autophagy
- Colonic Neoplasms