Radical host-specific therapies for TB.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23622234.
- Also identified by DOI 10.1016/j.cell.2013.04.019.
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Abstract
Although proinflammatory cytokines such as TNF are critical for containment of tuberculosis, they can also exacerbate disease when produced at high levels. In this issue of Cell, Roca and Ramakrishnan demonstrate that high TNF production induces reactive oxygen species in infected macrophages, ultimately leading to macrophage necrosis and bacterial dissemination.