On your mark, get SET(D2), go! H3K36me3 primes DNA mismatch repair.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23622237.
- Also identified by DOI 10.1016/j.cell.2013.04.018.
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Abstract
Trimethylation of histone H3 on Lys36 (H3K36me3) by SETD2 is linked to actively transcribed regions. Li et al. identify a novel role for H3K36me3 that facilitates DNA mismatch repair (MMR) in cells by targeting the MMR machinery to chromatin during the cell cycle, thereby explaining certain cases of MMR-defective cancers.