A comprehensive search for recombinogenic motifs in the human genome.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23626862.
- Also identified by DOI 10.1371/journal.pone.0062920 and PMC identifier 3633838.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The patterns of male and female recombination vary greatly on a macro scale. A unique motif in each gender, triggering a double strand break at its location, much in the way Chi sites operate in E. coli, could logically explain this difference. As such, we have undertaken a comprehensive search of all small motifs in an attempt to identify one or more that match to the available data. In the end, we conclude that no such motifs appear to exist in the human genome.
Medical subject headings
- Genome, Human
- Nucleotide Motifs
- Recombination, Genetic