Synthetic oleanane triterpenoids: magic bullets or not?
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 23633050.
- Also identified by DOI 10.1038/ki.2013.38.
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Abstract
A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME analog increases GFR by increasing glomerular surface area. However, changes in other renal hemodynamic parameters cannot be excluded. Vigorous testing of CDDO-ME and highly purified analogs is warranted to determine their physiology, pharmacology, and efficacy and to exclude serious side effects.
Medical subject headings
- Angiotensin II
- Cell Shape
- Glomerular Filtration Rate
- Mesangial Cells
- Oleanolic Acid