Protective efficacy of selenite against lead-induced neurotoxicity in Caenorhabditis elegans.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23638060.
- Also identified by DOI 10.1371/journal.pone.0062387 and PMC identifier 3637161.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
BACKGROUND: Selenium is an essential micronutrient that has a narrow exposure window between its beneficial and toxic effects. This study investigated the protective potential of selenite (IV) against lead (Pb(II))-induced neurotoxicity in Caenorhabditis elegans. PRINCIPAL FINDINGS: The results showed that Se(IV) (0.01 µM) pretreatment ameliorated the decline of locomotion behaviors (frequencies of body bends, head thrashes, and reversal ) of C. elegans that are damaged by Pb(II) (100 µM) exposure. The intracellular ROS level of C. elegans induced by Pb(II) exposure was significantly lowered by Se(IV) supplementation prior to Pb(II) exposure. Finally, Se(IV) protects AFD sensory neurons from Pb(II)-induced toxicity. CONCLUSIONS: Our study suggests that Se(IV) has protective activities against Pb(II)-induced neurotoxicity through its antioxidant property.
Medical subject headings
- Caenorhabditis elegans
- Lead
- Neuroprotective Agents
- Neurotoxins
- Sodium Selenite